Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer
In a prospective study we evaluated the efficacy of lycopene for the treatment of patients with metastatic hormone refractory prostate cancer.
Beauty from within: Improvement of skin health and appearance with Lycomato a tomato-derived oral supplement
Healthy and a youthful appearance is a common desire of the aging population. “Beauty from within” involves using nutrition and nutraceuticals to support skin function for reducing and reversing signs of aging such as wrinkles, pigmentary changes, skin laxity, and dullness. Carotenoids possess strong antioxidant and anti-inflammatory activities and are effective in improving skin barrier … Continued
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema
Carotenoids are suitable photoprotectants, and beta-carotene supplements are used for protection against ultraviolet (UV) light-induced erythema. Protective effects are also observed when carotenoids are provided with the diet. Here, we investigated the photoprotective effects of synthetic lycopene in comparison with a tomato extract (Lyc-o-Mato) and a drink containing solubilized Lyc-o-Mato (Lyc-o-Guard-Drink). With these different sources, … Continued
Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study
Increasing evidence suggests photoprotection by oral supplementation with β-carotene and lycopene.
Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients
Epidemiological studies have established that a low serum concentration of carotenoids was associated with risk of Age-Related Macular Degeneration (ARMD). The aim of this study was to determine carotenoid levels in serum and in different lipoprotein fractions in patients diagnosed for ARMD and in matched control group.
Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: Potential effects for human health
Molecular mechanisms associated with the anti-/pro-oxidative properties of carotenoids (CARs) are described in organic solvents, micro-heterogeneous environments and model lipid membranes and in cellular suspensions. Singlet oxygen is important in the skin and eye and CARs are efficient singlet oxygen (SO) quenchers with corresponding rate constants near diffusion controlled (typically app. 1010 M−1 s−1) with … Continued