Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy (PVR), which is the leading cause of failure in retinal reattachment surgery. Several studies have shown that platelet-derived growth factor (PDGF) exhibits chemotaxis and proliferation effects on RPE cells in PVR. In this study, the inhibitory effect of lycopene on PDGF-BB-induced ARPE19 cell migration is examined. In electric cell-substrate impedance sensing (ECIS) and Transwell migration assays, significant suppression of PDGF-BB-induced ARPE19 cell migration by lycopene is observed. Cell viability assays show no cytotoxicity of lycopene on RPE cells. Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation. However, PDGF-BB and lycopene show no effects on JNK activation. Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.
BRANCHBURG, N.J., Oct. 29, 2025 /PRNewswire/ — Lycored, the global leader in naturally derived carotenoids for the food, beverage and dietary supplement market, is expanding its ingredient capabilities with the...
BEIJING and TEL AVIV, Israel, Oct. 22, 2025 /PRNewswire/ — ADAMA (SZSE: 000553), a global leader in crop protection, has announced the appointment of Dafna Cohen-Asher as Chief Executive Officer of Lycored,...
Lycored Emulsions You’ve heard it this year; it’s time for your product’s colors to shine through their natural composition. In that context, it looks like our emulsion solutions come at...
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