Clinical Studies and Applications

Discover the range of our products in your consumer’s daily life

Overview

Our Dedication to Quality

Lycored is committed to delivering reliable and top-notch, quality ingredients that you can trust. We conduct extensive testing on our products ranging from stability in application to pre-clinical and clinical to ensure our portfolio of solutions’ effectiveness, resiliency, and bioavailability help your products stand out from the competition and meet consumer expectations.

Our in-depth knowledge of our products enables us to provide you and your consumers with the confidence and assurance that we all seek in our food and health products.

Our studies

Our Product's Performance

We can sing the praises of our products for days. But we prefer for our research and studies to speak for itself.

Because we care about consumers having trust in the products you offer, our work to improve and find out more about our products is never over. Scroll and browse through our body of research for each of our products.

TitleSummaryTagsLinkhf:doc_categorieshf:doc_tags
Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study☆

Lycopene, a nutritional antioxidant, was evaluated for its anticataract potential to further establish its role …

others lycopene-otherseye-health
Lycopene prevents sugar-induced morphological changes and modulates antioxidant status of human lens epithelial cells

Cataract is a multifactorial disease. Osmotic stress, together with weakened antioxidant defence mechanisms, is attributed …

others lycopene-otherseye-health
Plasma carotenoids and diabetic retinopathy

Diabetic retinopathy increases with duration of diabetes and may be associated with carotenoid status. Carotenoids …

, others lycopene-otherseye-health mens-health
Serum lycopene levels in patients with diabetic retinopathy

Accumulating evidence indicates that oxidative stress may play an important role in the pathogenesis of …

, others lycopene-otherseye-health mens-health
Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways

Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy …

others lycopene-otherseye-health
Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells

Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in …

others lycopene-otherseye-health
Serum carotenoids and risk of age-related macular degeneration in a chinese population sample

It has been hypothesized that the macular carotenoids protect against age-related macular degeneration (AMD). In …

others lycopene-otherseye-health
Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women

Lycopene is a carotenoid commonly found in tomatoes and tomato products which acts as an antioxidant to decrease oxidative …

, others lycopene-othersbone-health womens-health
Lycopene influences osteoblast functional activity and prevents femur bone loss in female rats submitted to an experimental model of osteoporosis

Antioxidant properties of several nutrients may influence bone metabolism, affording protection against damaging effects caused …

, others lycopene-othersbone-health womens-health
Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women

To date, no intervention studies have been published demonstrating the effect of the antioxidant lycopene …

, others lycopene-othersbone-health womens-health
Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density, which affects the …

, others lycopene-othersbone-health womens-health
Lycopene and bone: an in vitro investigation and a pilot prospective clinical study

There are several effective therapies for osteoporosis but these agents might cause serious adverse events. …

others lycopene-othersbone-health
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive …

others lycopene-othersskin-health
A Review on Benefits of Lycopene in Formulation of Sunscreen

Lycopene which is a carotenoid found in tomatoes and other red and orange fruits, has …

others lycopene-othersskin-health
Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials

The dietary supplement industry offers a wide range of orally consumed products that claim to …

others lycopene-othersskin-health
Skin Protection by Carotenoid Pigments

Sunlight, despite its benefits, can pose a threat to the skin, which is a natural …

others lycopene-othersskin-health
The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes

Lycopene has been reported as the antioxidant most quickly depleted in skin upon UV irradiation, …

others lycopene-othersskin-health
Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation

Lycopene is a dietary antioxidant known to prevent skin photodamage. This study aimed to examine …

others lycopene-othersskin-health
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials

Lycopene as a natural antioxidant that have been studied for ultraviolet radiation (UVR) photo protection …

others lycopene-othersskin-health
The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial

Infertility is a major, worldwide problem that is affected, and mediated, by several factors, in …

others lycopene-othersmens-health
The effects of tomato juice on male infertility

Background and Objectives: This study aimed to investigate the effects of tomato juice consumption on …

others lycopene-othersmens-health
Lycopene in male infertility

Male infertility is a major concern around the world, and efforts to find effective therapies …

others lycopene-othersmens-health
Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Varicocele is considered the main reason for male infertility. Antioxidants are common drugs used to …

others lycopene-othersmens-health
Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis

Lycopene, a carotenoid found in tomatoes and watermelon, has been investigated for its potential to …

others lycopene-othersmens-health
Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions

Benign prostatic hyperplasia, urolithiasis, recurrent urinary tract infections, and chronic prostatitis are diseases that are …

, others lycopene-othersmens-health prostate-health
Potential inhibitory effect of lycopene on prostate cancer

Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. …

, others lycopene-othersmens-health prostate-health
Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is identified as a urinary andrological diseases that afflict men …

, others lycopene-othersmens-health prostate-health
[Efficacy and safety of lycopene in the treatment of benign prostatic hyperplasia with lower urinary tract symptoms]

To investigate the efficacy and safety of lycopene in the treatment of BPH with lower …

, others lycopene-othersmens-health prostate-health
A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health

This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling …

others lycopene-othersoral-health
The effect of systemic lycopene supplementation on non-surgical periodontal therapy outcomes: A clinical trial

Some recent studies have suggested that antioxidants, particularly lycopene, may improve periodontal treatment outcomes. However, …

others lycopene-othersoral-health
Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease

This systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment …

others lycopene-othersoral-health
Promising hepatoprotective effects of lycopene in different liver diseases

The incidence of liver diseases such as hepatitis, fibrosis, cirrhosis, and liver cancer is one of the …

others lycopene-othersliver-health
Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-κB/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet

Lycopene (LY) belongs to carotenoids and is abundant in red fruits and vegetables. Several previous …

others lycopene-othersliver-health
Protective Role of Lycopene in Subjects with Liver Disease: NUTRIHEP Study

Liver diseases are constantly increasing throughout the world and are often associated with other diseases, …

others lycopene-othersliver-health
The Effects of Lycopene on Modulating Oxidative Stress and Liver Enzymes Levels in Metabolic Syndrome Patients: A Randomised Clinical Trial

The pathogenesis of metabolic syndrome (MetS) complications involves the excessive production of reactive oxygen species, …

others lycopene-othersliver-health
The Relationship Between Lycopene and Metabolic Diseases

Metabolic syndrome, obesity, and type 2 diabetes are closely related. They are characterized by chronic …

others lycopene-othersmetabolic-health
The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study

The use of lycopene as a complementary medicine for Type II diabetes mellitus (T2DM) is …

others lycopene-othersmetabolic-health
Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus

Nutrition is of utmost importance in chronic disease management and has often been described as …

others lycopene-othersmetabolic-health
Background: Lycopene, a dietary carotenoid with antioxidant properties, protects against sun-induced skin damage, prostatic conditions such as chronic prostatitis, and cancer; however, its role in metabolic disorders, including metabolic syndrome and nonalcoholic fatty liver disease (MAFLD), remains unclear. This study aimed to systematically assess the association between lycopene levels (serum and dietary) and the risk of metabolic diseases. Methods: This study adhered to the PRISMA guidelines and was prospectively registered on the Open Science Framework (OSF). We searched PubMed, Scopus, Web of Science, and Medline via WoS. Pooled odds ratios (OR), hazard ratios (HR), and mean differences (MD) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models based on heterogeneity. Results: Twenty-nine studies were included, of which twenty-five were eligible for the meta-analysis. Pooled analysis showed that the individuals with the lowest serum lycopene levels had a significantly higher risk of MAFLD (OR = 1.39, 95%CI: 1.02–1.89, p = 0.0388). No significant associations were found between HbA1c levels, diabetes history, and weight status. Although not statistically significant, a clear trend of patients with DM having lower lycopene levels than the control group was observed (MD = −0.09, 95% CI: −0.19 to 0.00, p = 0.054). Comparisons based on weight status showed no significant differences. Conclusions: While lower serum lycopene levels are significantly associated with increased MAFLD risk, their impact on glycemic control remains inconclusive, underscoring the need for targeted clinical research.

Lycopene is a lipophilic unsaturated carotenoid exhibiting a strong singlet oxygen-quenching ability. Herein, we investigated …

others lycopene-othersmetabolic-health
Association Between Lycopene and Metabolic Disease Risk and Mortality: Systematic Review and Meta-Analysis

Background: Lycopene, a dietary carotenoid with antioxidant properties, protects against sun-induced skin damage, prostatic conditions …

, others lycopene-othersliver-health metabolic-health
Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials

Hypertension is a predisposing factor for cardiovascular disease (CVD). Results of previous clinical trials on …

others lycopene-othersheart-health
Lycopene for Cardiovascular Health: Preclinical to Clinical Evidence

Cardiovascular disorder is a significant source of illness and destruction in the US and worldwide. …

others lycopene-othersheart-health
Lycopene and Cardiovascular Health: A Systematic Review Reveals Promising Benefits in Blood Pressure, Lipid Profiles, and Oxidative Stress

Cardiovascular disease remains a leading global cause of mortality, demanding effective prevention and management. This …

others lycopene-othersheart-health
Lycopene in the Prevention of Cardiovascular Diseases

Cardiovascular diseases (CVDs) are the leading cause of human mortality worldwide. Oxidative stress and inflammation …

others lycopene-othersheart-health
Effect of Dietary and Supplemental Lycopene on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis

Cardiovascular disease (CVD) is the leading cause of death globally and the presence of ≥1 …

others lycopene-othersheart-health
Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors

Foods rich in antioxidants such as lycopene have a major role in maintaining cardiac health. …

others lycopene-othersheart-health
Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, …

others lycopene-othersheart-health
Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials

Diet, physical activity, and other lifestyle factors have been implicated in the pathophysiology of several chronic …

others lycopene-otherscellular-wellness
Pharmacological potentials of lycopene against aging and aging-related disorders: A review

Aging and aging-related chronic disorders are one of the principal causes of death worldwide. The …

others lycopene-otherscellular-wellness
Lycopene: A Potent Antioxidant with Multiple Health Benefits

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato-based products. Like other …

, , , others lycopene-othersbone-health eye-health heart-health metabolic-health
Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based …

, , others lycopene-otherscellular-wellness heart-health skin-health
Lycomato Cellular Wellness Scientific Summary

Lycomato supports immune health by protecting cells from oxidative stress and inflammation that can weaken …

lycomato lycoredcellular-wellness
ARE/Nrf2 Transcription System Involved in Carotenoid, Polyphenol, and Estradiol Protection from Rotenone-Induced Mitochondrial Oxidative Stress in Dermal Fibroblasts

Skin aging is associated with the increased production of mitochondrial reactive oxygen species (mtROS) due …

lycomato lycoredcellular-wellness
Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer

In a prospective study we evaluated the efficacy of lycopene for the treatment of patients …

lycomato lycoredmens-health
Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects

To investigate the effects of a lutein complex supplementation on ocular blood flow in healthy …

lutein lycoredeye-health
Characterizing the effect of supplements on the phenotype of cultured macrophages from patients with age-related macular degeneration

Oral vitamin and mineral supplements reduce the risk of visual loss in age-related macular degeneration …

lutein lycoredeye-health
Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, …

astaxanthin lycoredcellular-energy
Effect of Lumenato oral supplementation on plasma carotenoid levels and improvement of visual and experiential skin attributes

Cellular metabolism and exposure to solar irradiation result in generation of free radicals which are …

lumenato lycored
Effect of Lumenato a Tomato derived oral supplement on improving skin barrier strength

Improvement of skin barrier strength could lead to healthy and youthful appearance. “Beauty inside-out” approach …

lumenato lycoredskin-health
Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects

Low-density lipoprotein (LDL) oxidation is a risk factor for atherosclerosis. Lycopene and tomato-based products have …

cardiomato lycoredheart-health
Effect of Cardio Mato (Grade A Lyc-O-Mato, a Tomato Extracted Lycopene) on Blood Pressure

Blood-pressure reading of 140/90 mmHg (systolic/diastolic pressure) are typically regarded as having high blood pressure …

cardiomato lycoredheart-health
Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study

Our previous double-blinded, placebo-controlled cross-over study indicated that a nutritional supplement named lycopene-rich tomato nutrient …

lycoderm lycoredskin-health
Combined Effects of Carotenoids and Polyphenols in Balancing the Response of Skin Cells to UV Irradiation

Oral carotenoids and polyphenols have been suggested to induce photo-protective effects. The aim of the …

lycoderm lycoredskin-health
Beauty from within: Improvement of skin health and appearance with Lycomato a tomato-derived oral supplement

Healthy and a youthful appearance is a common desire of the aging population. “Beauty from …

lycomato lycoredskin-health
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema

Carotenoids are suitable photoprotectants, and beta-carotene supplements are used for protection against ultraviolet (UV) light-induced …

lycomato lycoredskin-health
Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study

Increasing evidence suggests photoprotection by oral supplementation with β-carotene and …

lycored lycomato lycopene-lycoredskin-health
Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients

Epidemiological studies have established that a low serum concentration of carotenoids was associated with risk …

lycored lycomato lycopene-lycoredeye-health
Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: Potential effects for human health

Molecular mechanisms associated with the anti-/pro-oxidative properties of carotenoids (CARs) are described in organic solvents, …

lycomato lycoredeye-health
Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study

Oxidative stress is implicated in the pathogenesis of essential hypertension, a risk factor for cardiovascular …

lycomato lycoredheart-health
43 CrossRef citations to date 3 Altmetric Original Articles Synergistic Anti-Oxidative Effects of Lycopene with Other Bioactive Compounds

Lycopene belongs to the carotenoid family, which has more than 700 members. In human serum, …

lycored lycomato lycopene-lycoredheart-health
Lycopene inhibits disease progression in patients with benign prostate hyperplasia

Lycopene is a promising nutritional component for chemoprevention of prostate cancer (PCa). A possibly beneficial …

lycored lycomato lycopene-lycoredmens-health
The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity

Epidemiological studies have consistently shown that regular consumption of fruits and vegetables is strongly associated …

lycomato lycoredmens-health
Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women

To date, no intervention studies have been published demonstrating the effect of the antioxidant lycopene …

lycored lycomato lycopene-lycoredwomens-health
Lycopene and other carotenoids inhibit estrogenic activity of 17 β-estradiol and genistein in cancer cells

Epidemiological evidence suggests that carotenoids prevent several types of cancer, including mammary and endometrial cancers. …

lycored lycomato lycopene-lycoredwomens-health
Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells

Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in …

lycomato lycoredwomens-health
Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study

lycomato lycoredcellular-wellness
Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

The objective was to determine the effects of lycopene supplementation on endothelial function assessed by …

lycored lycomato lycopene-lycoredcellular-wellness

Benefits

Health Associations

These days, health-savvy consumers are taking better care of themselves with highly tailored exercise and diet routines. They also demand transparency when it comes to wellness products. Our products are designed for wholesome efficiency.

See which of our products benefit each specific area of the body below. Click on any of the tabs to learn more.

Cellular Wellness

After extensive research, we found just what it is that the heart wants: calm.

Click below to learn about our solutins for calm oriented products:

Skin Health

Skin health encompasses suncare, apppearance but also generalk health. The biggest of our organs deserves our care and attention, discover our skin health benefits pages below:

 

Heart Health

Your heart sets the rythm for the life you live. Discover our heart oriented products below:

Eye Health

The human eye is capable of incredible things, like differentiating between more than 10 million colors and detecting the tiniest particles. Discover the products we formulated to set this incredible organ for success:

Cellular Energy

Exercise supports your body’s health but who is going to support your recovery from exercise? Discover our sports nutrition portfolio below:

Men's Health

Men’s health comes with its own group of concerns including hormonal balance, prostate health and comfort, fertility management, and energy maintenance. By targeting and prioritizing these areas, we can help promote overall wellness.

Explore our men’s health solutions:

Women's Health

Supporting women’s health through our work is not only a selling point but a logical continuation of supporting people’s right to wellness. Through our lycopene products, we can help alleviate the effects of hormonal health on everyday life.

Explore our women’s health solutions:

  • Cellular Wellness
  • Skin Health
  • Heart Health
  • Eye Health
  • Cellular Energy
  • Men's Health
  • Women's Health

Applications

Our Products in Applications

Lycored offers solutions for food and nutraceutical products, working to deliver the best nature offers to you and your consumers. But high-quality ingredients, nutrients, and actives are not enough, we want our products to help you offer solutions that fit your audience best.

Discover what applications our products can work with.

We're here for you

Interested in speaking directly with a member of our team?
Click below to get in touch.

Contact us