Clinical Studies and Applications
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Overview
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Lycored is committed to delivering reliable and top-notch, quality ingredients that you can trust. We conduct extensive testing on our products ranging from stability in application to pre-clinical and clinical to ensure our portfolio of solutions’ effectiveness, resiliency, and bioavailability help your products stand out from the competition and meet consumer expectations.
Our in-depth knowledge of our products enables us to provide you and your consumers with the confidence and assurance that we all seek in our food and health products.
Our studies
Our Product's Performance
We can sing the praises of our products for days. But we prefer for our research and studies to speak for itself.
Because we care about consumers having trust in the products you offer, our work to improve and find out more about our products is never over. Scroll and browse through our body of research for each of our products.
| Title | Summary | Tags | Link | hf:doc_categories | hf:doc_tags |
|---|---|---|---|---|---|
| Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study☆ | Lycopene, a nutritional antioxidant, was evaluated for its anticataract potential to further establish its role … | Eye Health | others lycopene-others | eye-health | |
| Lycopene prevents sugar-induced morphological changes and modulates antioxidant status of human lens epithelial cells | Cataract is a multifactorial disease. Osmotic stress, together with weakened antioxidant defence mechanisms, is attributed … | Eye Health | others lycopene-others | eye-health | |
| Plasma carotenoids and diabetic retinopathy | Diabetic retinopathy increases with duration of diabetes and may be associated with carotenoid status. Carotenoids … | Eye Health, Men's Health | others lycopene-others | eye-health mens-health | |
| Serum lycopene levels in patients with diabetic retinopathy | Accumulating evidence indicates that oxidative stress may play an important role in the pathogenesis of … | Eye Health, Men's Health | others lycopene-others | eye-health mens-health | |
| Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways | Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy … | Eye Health | others lycopene-others | eye-health | |
| Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells | Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in … | Eye Health | others lycopene-others | eye-health | |
| Serum carotenoids and risk of age-related macular degeneration in a chinese population sample | It has been hypothesized that the macular carotenoids protect against age-related macular degeneration (AMD). In … | Eye Health | others lycopene-others | eye-health | |
| Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women | Lycopene is a carotenoid commonly found in tomatoes and tomato products which acts as an antioxidant to decrease oxidative … | Bone Health, Women's Health | others lycopene-others | bone-health womens-health | |
| Lycopene influences osteoblast functional activity and prevents femur bone loss in female rats submitted to an experimental model of osteoporosis | Antioxidant properties of several nutrients may influence bone metabolism, affording protection against damaging effects caused … | Bone Health, Women's Health | others lycopene-others | bone-health womens-health | |
| Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women | To date, no intervention studies have been published demonstrating the effect of the antioxidant lycopene … | Bone Health, Women's Health | others lycopene-others | bone-health womens-health | |
| Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies | Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density, which affects the … | Bone Health, Women's Health | others lycopene-others | bone-health womens-health | |
| Lycopene and bone: an in vitro investigation and a pilot prospective clinical study | There are several effective therapies for osteoporosis but these agents might cause serious adverse events. … | Bone Health | others lycopene-others | bone-health | |
| Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2 | Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive … | Skin Health | others lycopene-others | skin-health | |
| A Review on Benefits of Lycopene in Formulation of Sunscreen | Lycopene which is a carotenoid found in tomatoes and other red and orange fruits, has … | Skin Health | others lycopene-others | skin-health | |
| Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials | The dietary supplement industry offers a wide range of orally consumed products that claim to … | Skin Health | others lycopene-others | skin-health | |
| Skin Protection by Carotenoid Pigments | Sunlight, despite its benefits, can pose a threat to the skin, which is a natural … | Skin Health | others lycopene-others | skin-health | |
| The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes | Lycopene has been reported as the antioxidant most quickly depleted in skin upon UV irradiation, … | Skin Health | others lycopene-others | skin-health | |
| Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation | Lycopene is a dietary antioxidant known to prevent skin photodamage. This study aimed to examine … | Skin Health | others lycopene-others | skin-health | |
| The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials | Lycopene as a natural antioxidant that have been studied for ultraviolet radiation (UVR) photo protection … | Skin Health | others lycopene-others | skin-health | |
| The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial | Infertility is a major, worldwide problem that is affected, and mediated, by several factors, in … | Men's Health | others lycopene-others | mens-health | |
| The effects of tomato juice on male infertility | Background and Objectives: This study aimed to investigate the effects of tomato juice consumption on … | Men's Health | others lycopene-others | mens-health | |
| Lycopene in male infertility | Male infertility is a major concern around the world, and efforts to find effective therapies … | Men's Health | others lycopene-others | mens-health | |
| Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia | Varicocele is considered the main reason for male infertility. Antioxidants are common drugs used to … | Men's Health | others lycopene-others | mens-health | |
| Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis | Lycopene, a carotenoid found in tomatoes and watermelon, has been investigated for its potential to … | Men's Health | others lycopene-others | mens-health | |
| Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions | Benign prostatic hyperplasia, urolithiasis, recurrent urinary tract infections, and chronic prostatitis are diseases that are … | Men's Health, Prostate Health | others lycopene-others | mens-health prostate-health | |
| Potential inhibitory effect of lycopene on prostate cancer | Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. … | Men's Health, Prostate Health | others lycopene-others | mens-health prostate-health | |
| Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats | Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is identified as a urinary andrological diseases that afflict men … | Men's Health, Prostate Health | others lycopene-others | mens-health prostate-health | |
| [Efficacy and safety of lycopene in the treatment of benign prostatic hyperplasia with lower urinary tract symptoms] | To investigate the efficacy and safety of lycopene in the treatment of BPH with lower … | Men's Health, Prostate Health | others lycopene-others | mens-health prostate-health | |
| A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health | This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling … | Oral Health | others lycopene-others | oral-health | |
| The effect of systemic lycopene supplementation on non-surgical periodontal therapy outcomes: A clinical trial | Some recent studies have suggested that antioxidants, particularly lycopene, may improve periodontal treatment outcomes. However, … | Oral Health | others lycopene-others | oral-health | |
| Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease | This systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment … | Oral Health | others lycopene-others | oral-health | |
| Promising hepatoprotective effects of lycopene in different liver diseases | The incidence of liver diseases such as hepatitis, fibrosis, cirrhosis, and liver cancer is one of the … | Liver Health | others lycopene-others | liver-health | |
| Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-κB/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet | Lycopene (LY) belongs to carotenoids and is abundant in red fruits and vegetables. Several previous … | Liver Health | others lycopene-others | liver-health | |
| Protective Role of Lycopene in Subjects with Liver Disease: NUTRIHEP Study | Liver diseases are constantly increasing throughout the world and are often associated with other diseases, … | Liver Health | others lycopene-others | liver-health | |
| The Effects of Lycopene on Modulating Oxidative Stress and Liver Enzymes Levels in Metabolic Syndrome Patients: A Randomised Clinical Trial | The pathogenesis of metabolic syndrome (MetS) complications involves the excessive production of reactive oxygen species, … | Liver Health | others lycopene-others | liver-health | |
| The Relationship Between Lycopene and Metabolic Diseases | Metabolic syndrome, obesity, and type 2 diabetes are closely related. They are characterized by chronic … | Metabolic Health | others lycopene-others | metabolic-health | |
| The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case–control study | The use of lycopene as a complementary medicine for Type II diabetes mellitus (T2DM) is … | Metabolic Health | others lycopene-others | metabolic-health | |
| Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus | Nutrition is of utmost importance in chronic disease management and has often been described as … | Metabolic Health | others lycopene-others | metabolic-health | |
| Background: Lycopene, a dietary carotenoid with antioxidant properties, protects against sun-induced skin damage, prostatic conditions such as chronic prostatitis, and cancer; however, its role in metabolic disorders, including metabolic syndrome and nonalcoholic fatty liver disease (MAFLD), remains unclear. This study aimed to systematically assess the association between lycopene levels (serum and dietary) and the risk of metabolic diseases. Methods: This study adhered to the PRISMA guidelines and was prospectively registered on the Open Science Framework (OSF). We searched PubMed, Scopus, Web of Science, and Medline via WoS. Pooled odds ratios (OR), hazard ratios (HR), and mean differences (MD) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models based on heterogeneity. Results: Twenty-nine studies were included, of which twenty-five were eligible for the meta-analysis. Pooled analysis showed that the individuals with the lowest serum lycopene levels had a significantly higher risk of MAFLD (OR = 1.39, 95%CI: 1.02–1.89, p = 0.0388). No significant associations were found between HbA1c levels, diabetes history, and weight status. Although not statistically significant, a clear trend of patients with DM having lower lycopene levels than the control group was observed (MD = −0.09, 95% CI: −0.19 to 0.00, p = 0.054). Comparisons based on weight status showed no significant differences. Conclusions: While lower serum lycopene levels are significantly associated with increased MAFLD risk, their impact on glycemic control remains inconclusive, underscoring the need for targeted clinical research. | Lycopene is a lipophilic unsaturated carotenoid exhibiting a strong singlet oxygen-quenching ability. Herein, we investigated … | Metabolic Health | others lycopene-others | metabolic-health | |
| Association Between Lycopene and Metabolic Disease Risk and Mortality: Systematic Review and Meta-Analysis | Background: Lycopene, a dietary carotenoid with antioxidant properties, protects against sun-induced skin damage, prostatic conditions … | Liver Health, Metabolic Health | others lycopene-others | liver-health metabolic-health | |
| Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials | Hypertension is a predisposing factor for cardiovascular disease (CVD). Results of previous clinical trials on … | Heart Health | others lycopene-others | heart-health | |
| Lycopene for Cardiovascular Health: Preclinical to Clinical Evidence | Cardiovascular disorder is a significant source of illness and destruction in the US and worldwide. … | Heart Health | others lycopene-others | heart-health | |
| Lycopene and Cardiovascular Health: A Systematic Review Reveals Promising Benefits in Blood Pressure, Lipid Profiles, and Oxidative Stress | Cardiovascular disease remains a leading global cause of mortality, demanding effective prevention and management. This … | Heart Health | others lycopene-others | heart-health | |
| Lycopene in the Prevention of Cardiovascular Diseases | Cardiovascular diseases (CVDs) are the leading cause of human mortality worldwide. Oxidative stress and inflammation … | Heart Health | others lycopene-others | heart-health | |
| Effect of Dietary and Supplemental Lycopene on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis | Cardiovascular disease (CVD) is the leading cause of death globally and the presence of ≥1 … | Heart Health | others lycopene-others | heart-health | |
| Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors | Foods rich in antioxidants such as lycopene have a major role in maintaining cardiac health. … | Heart Health | others lycopene-others | heart-health | |
| Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases | Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, … | Heart Health | others lycopene-others | heart-health | |
| Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials | Diet, physical activity, and other lifestyle factors have been implicated in the pathophysiology of several chronic … | Cellular Wellness | others lycopene-others | cellular-wellness | |
| Pharmacological potentials of lycopene against aging and aging-related disorders: A review | Aging and aging-related chronic disorders are one of the principal causes of death worldwide. The … | Cellular Wellness | others lycopene-others | cellular-wellness | |
| Lycopene: A Potent Antioxidant with Multiple Health Benefits | Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato-based products. Like other … | Bone Health, Eye Health, Heart Health, Metabolic Health | others lycopene-others | bone-health eye-health heart-health metabolic-health | |
| Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders | Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based … | Cellular Wellness, Heart Health, Skin Health | others lycopene-others | cellular-wellness heart-health skin-health | |
| Lycomato Cellular Wellness Scientific Summary | Lycomato supports immune health by protecting cells from oxidative stress and inflammation that can weaken … | Cellular Wellness | lycomato lycored | cellular-wellness | |
| ARE/Nrf2 Transcription System Involved in Carotenoid, Polyphenol, and Estradiol Protection from Rotenone-Induced Mitochondrial Oxidative Stress in Dermal Fibroblasts | Skin aging is associated with the increased production of mitochondrial reactive oxygen species (mtROS) due … | Cellular Wellness | lycomato lycored | cellular-wellness | |
| Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer | In a prospective study we evaluated the efficacy of lycopene for the treatment of patients … | Men's Health | lycomato lycored | mens-health | |
| Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects | To investigate the effects of a lutein complex supplementation on ocular blood flow in healthy … | Eye Health | lutein lycored | eye-health | |
| Characterizing the effect of supplements on the phenotype of cultured macrophages from patients with age-related macular degeneration | Oral vitamin and mineral supplements reduce the risk of visual loss in age-related macular degeneration … | Eye Health | lutein lycored | eye-health | |
| Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins | Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, … | Cellular Energy | astaxanthin lycored | cellular-energy | |
| Effect of Lumenato oral supplementation on plasma carotenoid levels and improvement of visual and experiential skin attributes | Cellular metabolism and exposure to solar irradiation result in generation of free radicals which are … | lumenato lycored | |||
| Effect of Lumenato a Tomato derived oral supplement on improving skin barrier strength | Improvement of skin barrier strength could lead to healthy and youthful appearance. “Beauty inside-out” approach … | Skin Health | lumenato lycored | skin-health | |
| Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects | Low-density lipoprotein (LDL) oxidation is a risk factor for atherosclerosis. Lycopene and tomato-based products have … | Heart Health | cardiomato lycored | heart-health | |
| Effect of Cardio Mato (Grade A Lyc-O-Mato, a Tomato Extracted Lycopene) on Blood Pressure | Blood-pressure reading of 140/90 mmHg (systolic/diastolic pressure) are typically regarded as having high blood pressure … | Heart Health | cardiomato lycored | heart-health | |
| Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study | Our previous double-blinded, placebo-controlled cross-over study indicated that a nutritional supplement named lycopene-rich tomato nutrient … | Skin Health | lycoderm lycored | skin-health | |
| Combined Effects of Carotenoids and Polyphenols in Balancing the Response of Skin Cells to UV Irradiation | Oral carotenoids and polyphenols have been suggested to induce photo-protective effects. The aim of the … | Skin Health | lycoderm lycored | skin-health | |
| Beauty from within: Improvement of skin health and appearance with Lycomato a tomato-derived oral supplement | Healthy and a youthful appearance is a common desire of the aging population. “Beauty from … | Skin Health | lycomato lycored | skin-health | |
| Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema | Carotenoids are suitable photoprotectants, and beta-carotene supplements are used for protection against ultraviolet (UV) light-induced … | Skin Health | lycomato lycored | skin-health | |
| Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study | Increasing evidence suggests photoprotection by oral supplementation with β-carotene and … | Skin Health | lycored lycomato lycopene-lycored | skin-health | |
| Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients | Epidemiological studies have established that a low serum concentration of carotenoids was associated with risk … | Eye Health | lycored lycomato lycopene-lycored | eye-health | |
| Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: Potential effects for human health | Molecular mechanisms associated with the anti-/pro-oxidative properties of carotenoids (CARs) are described in organic solvents, … | Eye Health | lycomato lycored | eye-health | |
| Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study | Oxidative stress is implicated in the pathogenesis of essential hypertension, a risk factor for cardiovascular … | Heart Health | lycomato lycored | heart-health | |
| 43 CrossRef citations to date 3 Altmetric Original Articles Synergistic Anti-Oxidative Effects of Lycopene with Other Bioactive Compounds | Lycopene belongs to the carotenoid family, which has more than 700 members. In human serum, … | Heart Health | lycored lycomato lycopene-lycored | heart-health | |
| Lycopene inhibits disease progression in patients with benign prostate hyperplasia | Lycopene is a promising nutritional component for chemoprevention of prostate cancer (PCa). A possibly beneficial … | Men's Health | lycored lycomato lycopene-lycored | mens-health | |
| The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity | Epidemiological studies have consistently shown that regular consumption of fruits and vegetables is strongly associated … | Men's Health | lycomato lycored | mens-health | |
| Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women | To date, no intervention studies have been published demonstrating the effect of the antioxidant lycopene … | Women's Health | lycored lycomato lycopene-lycored | womens-health | |
| Lycopene and other carotenoids inhibit estrogenic activity of 17 β-estradiol and genistein in cancer cells | Epidemiological evidence suggests that carotenoids prevent several types of cancer, including mammary and endometrial cancers. … | Women's Health | lycored lycomato lycopene-lycored | womens-health | |
| Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells | Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in … | Women's Health | lycomato lycored | womens-health | |
| Effect of Tomato Nutrient Complex on Blood Pressure: A Double Blind, Randomized Dose⁻Response Study | … | Cellular Wellness | lycomato lycored | cellular-wellness | |
| Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men | The objective was to determine the effects of lycopene supplementation on endothelial function assessed by … | Cellular Wellness | lycored lycomato lycopene-lycored | cellular-wellness |
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